Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are key indicators of kidney decline. However, it is unclear if these biomarkers are independent predictors of kidney disease progression in people with type 2 diabetes mellitus (T2DM).
ACR and eGFR as predictors of cardio-renal outcomes in diabetes and kidney disease
Keith C Norris, Karen E Smoyer, Catherine Rolland, Jan Van der Vaart, Elizabeth Grubb
BMC Nephrol. 2018;19(1):36.
Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are key indicators of kidney decline. However, it is unclear if these biomarkers are independent predictors of kidney disease progression in people with type 2 diabetes mellitus (T2DM). In this systematic literature review, the authors examined the literature documenting the role of albuminuria, serum creatinine, eGFR and uric acid in predicting kidney disease progression and cardio-renal outcomes in people with T2DM.
The authors found that kidney disease progression differed substantially across publications and that the biomarker measurements were diverse. They also noted that GFR loss and the doubling of serum creatinine were the most frequently reported outcome measures. Numerous publications also presented risk estimates for albuminuria and serum creatinine, or both.
The authors concluded that, despite the utility of albuminuria, serum creatinine and eGFR as predictors of kidney disease progression, effort is required to harmonize biomarker measurements. This would help better establish the clinical significance of these biomarkers in people with T2DM.
The full publication can be accessed here.
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