Eun Hee Nah, Seon Cho, Suyoung Kim, Han Ik Cho
Ann Lab Med. 2017;37(1):28-33.
In this study, the authors evaluated the clinical value of a point-of-care test (POCT) for measuring the urinary albumin-creatinine ratio (ACR) in prediabetes and diabetes. The group obtained spot urine samples from 226 prediabetic and 275 diabetic individuals during regular health checkups and measured urinary ACR by using point-of-care and laboratory quantitative tests.
The study found that the positive rates of albuminuria measured by the ACR POCT were 15.5% in prediabetes and 30.5% in diabetes. In the prediabetic population, the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of the POCT were 92.0%, 94.0%, 65.7%, 99.0% and 93.8%, respectively; the corresponding values in the diabetic population were 80.0%, 91.6%, 81.0%, 91.1%, and 88.0%, respectively. The median ACR values in the point-of-care tests for measurement ranges of <30, 30-300 and >300 mg/g were 9.4, 46.9 and 368.8 mg/g, respectively, using the laboratory method.
The authors conclude that the ACR point-of-care test demonstrated high sensitivity, specificity and negative predictive value. This suggests that the test can be used to screen for albuminuria in cases of prediabetes and diabetes.
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